The Only 3-in-1 Medical Food for Depression

Frequently Asked Questions

Here are answers to other often asked questions:

What is Hedonia? 

Hedonia is a medical food specifically formulated to address nutritional deficiencies associated with depression and enhance the effectiveness of antidepressant treatments. It's patented 3-in-1 formula was developed by Alexander Vuckovic MD, a renowned psychiatrist, pharmacologist, and Ivy League University professor of Psychiatry.


Hedonia is the first and only medical food to deliver the right dosage of 3 key clinically studied nutrients to help correct the nutritional imbalances associated with people suffering from depression. These 3 nutrients are S-adenosylmethionine (SAMe); to help support serotonin and dopamine receptor site binding, L-Methylfolate; to help support healthy serotonin levels in the brain and EPA/Omega-3 fatty acid; to help correct for low levels associated with chronic neuro-inflammation.


 In 2013 and then later in 2017, Hedonia was granted patents for the use of these three ingredients combined in specific proportions as a nutritional tool for the dietary management of depressive disorders.

As a Medical Food, how is Hedonia different from ordinary supplements? 

Hedonia is not a supplement or a drug. It is a patented breakthrough medical food for the management of depression. Medical Foods are a distinct category defined by the Orphan Drug Act of 1988. 


Unlike general supplements, medical foods are formulated to meet the distinctive nutritional requirements associated with particular diseases or conditions. They are an important and often complementary category of therapeutic agents known to address disease through a nutritional pathway.Hedonia embodies this definition by addressing the specific nutritional deficiencies often seen in individuals with depression. This targeted, science-based approach sets Hedonia apart from general supplements. 


Hedonia offers a level of specificity and quality not typically found in over-the-counter products, providing a more focused and potentially more effective nutritional intervention for individuals struggling with depression.  As a medical food, Hedonia is subject to stricter FDA guidelines than typical supplements. It's manufactured to Current Good Manufacturing Practice, (cGMP) ensuring consistent quality and potency. Well-known medical foods brands include Pedialyte and Ensure. 

How long does it take to feel the effects of Hedonia? 

Everyone’s brain chemistry is different. While you may feel the effects of Hedonia in a few weeks to a couple of months after starting treatment, many people notice some beneficial effects much sooner. For optimal results and to experience the full benefits of Hedonia, take two capsules in the morning and two in the evening. This consistent dosage ensures continuous support for your brain's neurotransmitter levels, promoting sustained well-being and mental clarity.

Are there known weight gain, insomnia, or lower libido side effects associated with Hedonia?

Hedonia is not associated with weight gain, insomnia, or sexual dysfunction. If you are pregnant, nursing, diagnosed with bipolar disorder, and/or taking MAO Inhibitors, you should consult with your doctor first.

Do I need a prescription for Hedonia? 

No. Hedonia does not require a prescription as long as you are under the care of a physician for depression.

Can Hedonia be combined with any antidepressants? 

Yes. As a medical food, Hedonia complements all antidepressants. We always recommend you speak with your doctor before adding Hedonia to your daily routine.

How does Hedonia correct the unique nutritional imbalances of people with depression? 

Researchers have discovered that many people with depression have a nutritional deficiency different from the general population. This imbalance impacts your brain chemistry. 


Hedonia’s unique 3-in-1 formulation directly addresses the nutritional imbalance of those living with depression and raises the levels of these critical nutrients to normal, healthy levels. These 3 nutrients are L-Methylfolate; to help support healthy serotonin levels in the brain. S-Adenosylmethionine (SAMe) ; to help support serotonin and dopamine receptor site binding and EPA/Omega-3 fatty acid; to help correct for low levels associated with chronic neuro-inflammation.

Why is Hedonia Premium Priced? 

Hedonia is the first and only medical food to deliver the right dosage of 3 key clinically studied nutrients to help correct the nutritional imbalances and deficiencies associated with people suffering from depression. Unfortunately, these nutrients, while available individually, are often not of uniform quality or convenient to use and cannot be easily consumed at the levels sufficient to correct a depressed person’s deficiencies. 


Hedonia only sources the highest premium quality ingredients for optimum potency, absorption, and bioavailability. One of the key nutrients in Hedonia is SAMe. It is known to be very susceptible to light and when in contact with other key compounds can lose its potency. That’s why Hedonia is delivered in a dual chamber capsule design to ensure the right potency and bioavailability of the active ingredients. For these reasons, Hedonia costs more to manufacture. Hedonia is backed by a 60-day money-back policy. If you're not completely satisfied, we'll refund your purchase price. No Questions Asked.

Is Hedonia FDA-approved? 

Medical Foods are a distinct category defined by the Orphan Drug Act of 1988. While it doesn't require FDA pre-approval, it must comply with FDA regulations for medical foods, including good manufacturing practices and appropriate labeling.

Who is Alexander Vuckovic MD? 

Alexander Vuckovic MD is a renowned psychiatrist and pharmacologist with over 30 years of experience. He's an Ivy League professor who has dedicated his career to understanding the relationship between nutrition and mental health and serving patients in his private patients. Dr. Vuckovic developed Hedonia based on his extensive research and clinical experience.

What are the 3 main ingredients in Hedonia?

Hedonia is the only 3-in-1 patented Medical Food formulated for people who suffer from depression. Hedonia uses only the highest quality ingredients available, setting a new standard in terms of superior quality and potency. These ingredients are:


Superior S-Adenosylmethionine (SAMe):

  • Enhances neurotransmitter binding, improving brain communication.
  • Uses pharmaceutical-grade SAMe, the purest and most bioavailable form.
  • More bioavailable than standard versions.
  • Manufactured using a proprietary process for maximum stability and potency.
  • Higher bioavailability means more SAMe reaches your brain
  • Specific quantity: 300 mg of Aldonat Premium SAMe Stabilized Powder


Advanced Bioactive L-Methylfolate


  • Boosts serotonin production, supporting a more balanced mood.
  • Uses L-Methylfolate, the most bioactive form of folate available.
  • Already in its active form, ready for immediate use by your body.
  • Crucial for individuals with MTHFR gene variations.
  • Specific quantity 5.0 mg of L-Methylfolate Glucosamine as Quatrefolic.


Superior EPA Omega-3


  • Addresses chronic neuro-inflammation associated with depression.
  • Features OmegaTex, one of the highest and purest forms of fish oil available
  • 85% EPA concentration, significantly more potent than regular supplements which are generally in the 30%-40% range.
  • Delivers nearly twice the active EPA in each dose compared to standard supplements.
  • Specific quantity: 470 mg of OMEGATEX8500 Omega-3 Triglycerides of which EPA is 400 mg, 46 mg are other Omega-3 Fatty Acids, and 24 mg DHA

How do I take Hedonia? 

The recommended dosage is two capsules twice daily, preferably with meals. Always follow the instructions on the label or as directed by your healthcare provider.

Are there any age restrictions for taking Hedonia? 

Hedonia is formulated for adult use. If you're considering Hedonia for someone under 18, please consult with a healthcare provider first.

* What Are the Terms of the Special Introductory Offer? 

Hedonia is backed by science and comes with a 100% money-back guarantee. We want you to try Hedonia for 60 Days for you to feel the difference it makes in your life. That's why we've cut the cost in half for your first 2 months and offer a hassle-free money-back refund policy. If you don't feel better we'll refund every penny. No questions asked. 


After, this risk-free trial period, the price is 5.85/Day (178.95 every 30 days)for your monthly delivery of 120 capsules. Shipping is free and your order is backed by our 100% satisfaction guarantee. This means you can pause, change your delivery cadence or cancel your monthly shipment at any time.

Can't find what you're looking for? 

Reach out with any questions or concerns and someone from our Customer Service team will get back to you as soon as possible. Be sure to include your order number (if you have one), Email us at CustomerService@hedonia.com


Pedialyte and Ensure are registered trademarks of Abbott Laboratories